Persons who develop new symptoms consistent with COVID-19 more than 3 months after the date of symptom onset of the most recent illness episode should be retested. Persons with recurrent symptoms after the first 3 months who test positive should be considered infectious and remain isolated until they again meet the criteria for discontinuation of isolation or of transmission-based precautions. Contact tracing during the person’s second period of symptoms is warranted. For persons who develop new symptoms consistent with COVID-19 during the first 3 months since the date of symptom onset of the most recent illness episode, retesting may be warranted if alternative etiologies for the illness cannot be identified. If reinfection is suspected, repeat isolation and contact tracing may be needed. The determination of whether a patient with a subsequently positive test is contagious to others should be made on a case-by-case basis, in consultation with infectious diseases specialists and public health authorities, after review of available information (e.g., medical history, time from an initial positive test, RT-PCR Ct values, and presence of COVID-19 signs or symptoms).